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Year Number of Results
2000 1
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2002 1
2003 2
2004 1
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2007 3
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2009 4
2012 2
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2017 1
2024 0

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21 results

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Page 1
Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.
Singh AK, Riederer B, Krabbenhöft A, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U. Singh AK, et al. J Clin Invest. 2009 Mar;119(3):540-50. doi: 10.1172/JCI35541. Epub 2009 Feb 16. J Clin Invest. 2009. PMID: 19221439 Free PMC article.
The epithelial anion channel CFTR interacts with multiple PDZ domain-containing proteins. Heterologous expression studies have demonstrated that the Na+/H+ exchanger regulatory factors, NHERF1, NHERF2, and PDZK1 (NHERF3), modulate CFTR membrane retention, con …
The epithelial anion channel CFTR interacts with multiple PDZ domain-containing proteins. Heterologous expression studies have demons …
Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells.
Jansson K, Venugopal J, Sánchez G, Magenheimer BS, Reif GA, Wallace DP, Calvet JP, Blanco G. Jansson K, et al. J Membr Biol. 2015 Dec;248(6):1145-57. doi: 10.1007/s00232-015-9832-7. Epub 2015 Aug 20. J Membr Biol. 2015. PMID: 26289599 Free PMC article.
Ouabain (3 nM) enhanced cAMP-induced cyst-like dilations in embryonic kidneys from Pkd1 (m1Bei) mice, but had no effect on metanephroi from Pkd1 (m1Bei) mice that lack expression of the cystic fibrosis transmembrane conductance regulator (CFTR). Similarly, ouabain stimulat …
Ouabain (3 nM) enhanced cAMP-induced cyst-like dilations in embryonic kidneys from Pkd1 (m1Bei) mice, but had no effect on metanephroi from …
Influence of PDZK1 on lipoprotein metabolism and atherosclerosis.
Kocher O, Yesilaltay A, Shen CH, Zhang S, Daniels K, Pal R, Chen J, Krieger M. Kocher O, et al. Biochim Biophys Acta. 2008 May;1782(5):310-6. doi: 10.1016/j.bbadis.2008.02.004. Epub 2008 Mar 10. Biochim Biophys Acta. 2008. PMID: 18342019 Free PMC article.
PDZK1 is a scaffold protein containing four PDZ protein interaction domains, which bind to the carboxy termini of a number of membrane transporter proteins, including ion channels (e.g., CFTR) and cell surface receptors. ...However, unlike complete SR-BI-deficiency …
PDZK1 is a scaffold protein containing four PDZ protein interaction domains, which bind to the carboxy termini of a number of membran …
PDZK1 upregulation in estrogen-related hyperpigmentation in melasma.
Kim NH, Cheong KA, Lee TR, Lee AY. Kim NH, et al. J Invest Dermatol. 2012 Nov;132(11):2622-31. doi: 10.1038/jid.2012.175. Epub 2012 Jun 14. J Invest Dermatol. 2012. PMID: 22696060 Free article.
Microarray and real-time PCR analyses revealed that upregulation of PDZ domain protein kidney 1 (PDZK1) is clinically correlated with melasma. Although there has been no report that PDZK1 is involved in pigmentation and/or melanogenesis, PDZK1 expression can …
Microarray and real-time PCR analyses revealed that upregulation of PDZ domain protein kidney 1 (PDZK1) is clinically correlated with …
Regulated trafficking of the CFTR chloride channel.
Kleizen B, Braakman I, de Jonge HR. Kleizen B, et al. Eur J Cell Biol. 2000 Aug;79(8):544-56. doi: 10.1078/0171-9335-00078. Eur J Cell Biol. 2000. PMID: 11001491 Review.
Regulated trafficking of the CFTR Cl- channel has sofar been demonstrated only in a subset of CFTR-expressing cell types. However, with the introduction of more sensitive methods to measure CFTR cycling and submembrane localization, it might turn out to be a …
Regulated trafficking of the CFTR Cl- channel has sofar been demonstrated only in a subset of CFTR-expressing cell types. Howe …
Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes.
Pelaseyed T, Gustafsson JK, Gustafsson IJ, Ermund A, Hansson GC. Pelaseyed T, et al. Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C457-67. doi: 10.1152/ajpcell.00141.2013. Epub 2013 Jun 19. Am J Physiol Cell Physiol. 2013. PMID: 23784542 Free PMC article.
We have reported that transmembrane mucin MUC17 binds PDZ protein PDZK1, which retains MUC17 apically in enterocytes. MUC17 and transmembrane mucins MUC3 and MUC12 are suggested to build the enterocyte apical glycocalyx. ...CCh stimulation concomitantly internalized the Na …
We have reported that transmembrane mucin MUC17 binds PDZ protein PDZK1, which retains MUC17 apically in enterocytes. MUC17 and trans …
The cystic fibrosis transmembrane regulator forms macromolecular complexes with PDZ domain scaffold proteins.
Guggino WB. Guggino WB. Proc Am Thorac Soc. 2004;1(1):28-32. doi: 10.1513/pats.2306011. Proc Am Thorac Soc. 2004. PMID: 16113408 Review.
These data suggest that CFTR may exist in macromolecular complexes with these and other scaffolding proteins at the apical membrane. PDZ domain proteins have been shown to localize and cluster CFTR in the Golgi and at the plasma membrane. This review highlights the …
These data suggest that CFTR may exist in macromolecular complexes with these and other scaffolding proteins at the apical membrane. …
Down regulation of small intestinal ion transport in PDZK1- (CAP70/NHERF3) deficient mice.
Hillesheim J, Riederer B, Tuo B, Chen M, Manns M, Biber J, Yun C, Kocher O, Seidler U. Hillesheim J, et al. Pflugers Arch. 2007 Jul;454(4):575-86. doi: 10.1007/s00424-007-0239-x. Epub 2007 Mar 9. Pflugers Arch. 2007. PMID: 17347851
The PDZ-binding protein PDZK1 (CAP70/PDZ-dc-1/NHERF3) in vitro binds to cystic fibrosis transmembrane conductance regulator (CFTR), the anion exchangers SLC26A3 and SLC26A6 and the Na(+)/H(+) exchanger NHE3, all of which are major transport proteins for intestinal a …
The PDZ-binding protein PDZK1 (CAP70/PDZ-dc-1/NHERF3) in vitro binds to cystic fibrosis transmembrane conductance regulator (CFTR …
In vitro analysis of PDZ-dependent CFTR macromolecular signaling complexes.
Wu Y, Wang S, Li C. Wu Y, et al. J Vis Exp. 2012 Aug 13;(66):4091. doi: 10.3791/4091. J Vis Exp. 2012. PMID: 22907480 Free PMC article.
So far, several different PDZ scaffold proteins have been reported to bind to the carboxyl terminal tail of CFTR with various affinities, such as NHERF1, NHERF2, PDZK1, PDZK2, CAL (CFTR-associated ligand), Shank2, and GRASP(20-27). ...Interestingly, CFTR …
So far, several different PDZ scaffold proteins have been reported to bind to the carboxyl terminal tail of CFTR with various affinit …
21 results